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Abstract #2608

Pituitary R2 values at 3T to assess risk of iron-mediated hypogonadal hypogonadism.

Andrew L Cheng1, Thomas D Coates1, and John C Wood2

1Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States, 2Pediatrics and Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States

Pituitary R2 at 1.5 Tesla has been validated as a sensitive marker of pituitary siderosis and risk of clinical hypogonadism. We cross-validated pituitary R2 measurements at 3T and 1.5T in 26 patients with iron overload syndromes. Pituitary R2 scaled linearly across field strength with a relative enhancement of 42%, consistent with previous liver R2 cross-field validations. When 3T pituitary values were transformed into equivalent 1.5T R2 values, the resulting Z-score estimates were unbiased with native 1.5T R2 estimates. Thus it is not necessary to acquire normative R2 data at 3 Tesla in order to interpret 3T pituitary R2 values.

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