Abstract #2612

Plastic Changes of the Language-related Brain Regions for Children with Non-syndrome Cleft of Lip with or without Palate (NSCL/P)

Bo Rao¹, Hua Cheng¹, Yang Fan², Wenjing Zhang³, Xuhong Liao⁴, Renji Chen³, and Yun Peng¹

¹Beijing Children’s Hospital, Capital Medical University, beijing, China, ²MR Research China, GE Healthcare, beijing, China, ³Beijing Stomatological Hospital, Capital Medical University, beijing, China, ⁴Beijing Normal University, beijing, China

Using multimode MRI technique, this study attempt to find structural and functional alterations of brain regions for children with non-syndrome cleft of lip with or without palate (NSCL/P). Compared with control group, both structural and functional changes were detected in distributed cortical regions for NSCL/P group, which mainly located on the dorsal stream of language pathways. Besides, significant correlations were found between ALFF values and Chinese language clear degree scales for NSCL/P children.

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