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Abstract #2612

Plastic Changes of the Language-related Brain Regions for Children with Non-syndrome Cleft of Lip with or without Palate (NSCL/P)

Bo Rao1, Hua Cheng1, Yang Fan2, Wenjing Zhang3, Xuhong Liao4, Renji Chen3, and Yun Peng1

1Beijing Children’s Hospital, Capital Medical University, beijing, China, 2MR Research China, GE Healthcare, beijing, China, 3Beijing Stomatological Hospital, Capital Medical University, beijing, China, 4Beijing Normal University, beijing, China

Using multimode MRI technique, this study attempt to find structural and functional alterations of brain regions for children with non-syndrome cleft of lip with or without palate (NSCL/P). Compared with control group, both structural and functional changes were detected in distributed cortical regions for NSCL/P group, which mainly located on the dorsal stream of language pathways. Besides, significant correlations were found between ALFF values and Chinese language clear degree scales for NSCL/P children.

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