In this work, we hypothesize that the metabolic changes occurring in the brain of prion-infected mice due to conformational changes of prion protein can be mapped using CEST MRI following previous in vivo work. Our previous findings include reduced Nuclear Overhauser Effect mediated by exchange-relayed signals in thalamus and cortex of prion-infected mice possibly related to up normal prion protein folding. Here we extend our studies by including a rich multipower acquisition scheme for targeting exchange processes falling at different regimes. For understanding the origin of CEST signal alternations T1, T2, and MT maps are included as well as histological findings.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords