Abstract #2615

Ex-vivo MR investigation of microstructures in globus pallidus in QSM: a histological validation study

Jinhee Jang¹, Yoonho Nam¹, Tae-Ryong Riew², Sung Won Jung², Sang Hyun Kim^2,3, and In-Beom Kim ^2,3

¹Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ²Department of Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Catholic Institute for Applied Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of

Linear paramagnetic structures were frequently seen in globus pallidus (GP), and interesting calcific densities are overlapping on these paramagnetic structures. This study aimed to explore the microstructural findings of GP using ex-vivo MRI scan and histologic validation. We found that the source of paramagnetism were mineral deposition of perforating vessels in GP. Those mineral depositions were paramagnetic on MR images, and calcific density on CT scan. Histologic study showed simultaneous deposition of iron and calcium along the arterial wall. High resolution MRI might have potential to demonstrate vascular degeneration and mineral deposition, which might be associated with aging and metabolic brain diseases.

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