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Abstract #2618

Gradient profiles of myelin and microstructure metrics across the developing brain

Erika P Raven1, Maxime Chamberland1, Sila Genc1,2,3, Kate Duffy1, Chantal Tax1, Greg Parker1, Maxime Descoteaux4, and Derek K Jones1

1Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 2Developmental Imaging, Murdoch Children’s Research Institute, Parkville, Australia, 3Department of Paediatrics, University of Melbourne, Parkville, Australia, 4University of Sherbrooke, Sherbrooke, QC, Canada

Myelinogenesis follows a protracted sequence, with distinct pathways being myelinated at various times throughout development. To test this with MRI, we used magnetization transfer and diffusion metrics with tractography to investigate along-tract profiles of myelin and microstructure metrics in children and adolescents. Profiles demonstrated sensitivity to along-tract metrics, with midline regions having increased myelin and restricted diffusion indices indicative of maturation.

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