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Abstract #2620

Chemotherapy-induced gray matter abnormalities in cancer survivals: a voxel-wise neuroimaging meta-analysis.

Running Niu1, Mingying Du1, Lu Lu2, and Peng Zhou1

1Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 2Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China

The present meta-analysis investigated the grey matter abnormalities in non-CNS cancer survivals treated with chemotherapy using Anisotropic Effect Size Signed Differential Mapping (AES-SDM) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guides. Compared with controls, the non-CNS cancer survivals treated with chemotherapy exhibit widespread grey matter abnormalities in brain, especially in prefrontal-temporal pathway, which was significantly affected by the time length since chemotherapy. This pattern of grey matter volume changes might improve our understanding of the pathophysiological nature of chemotherapy related cognitive dysfunctions.

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