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Abstract #2621

Quantitative R2 mapping reveals information of myelin content in rat brain at 7T

Ping-Huei Tsai1,2, Tsai-Jou Su1, Hua-Shan Liu3, Fei-Ting Hsu4, Yu-Chieh Kao5, Chia-Feng Lu6, Hsiao-Wen Chung7, and Cheng-Yu Chen5

1Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, 3School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, 4Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, 5Research Center of Translational Imaging, School of Medicine, Taipei Medical University, Taipei, Taiwan, 6Department of Biomedical Imaging and Radiological Sciences, Yang Ming University, Taipei, Taiwan, 7Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

Information of myelin content can reflect the microstructural difference between brain white matter (WM) and gray matter (GM), and particularly facilitating in detection of WM abnormalities during disease progression. This study aims to optimize a quantitative R2 mapping method of rat brain at 7T MRI and to evaluate the relationship between the measured R2 values and myelin content in discrepant brain tissues. Our findings demonstrated that quantitative R2 measurements could be an alternative to provide information of myelin content in rat brain at 7T, which may have potential to assess microstructural changes of brain WM and GM in demyelinating diseases.

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