Abstract #2621

Quantitative R2 mapping reveals information of myelin content in rat brain at 7T

Ping-Huei Tsai^1,2, Tsai-Jou Su¹, Hua-Shan Liu³, Fei-Ting Hsu⁴, Yu-Chieh Kao⁵, Chia-Feng Lu⁶, Hsiao-Wen Chung⁷, and Cheng-Yu Chen⁵

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, ³School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan, ⁴Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, ⁵Research Center of Translational Imaging, School of Medicine, Taipei Medical University, Taipei, Taiwan, ⁶Department of Biomedical Imaging and Radiological Sciences, Yang Ming University, Taipei, Taiwan, ⁷Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

Information of myelin content can reflect the microstructural difference between brain white matter (WM) and gray matter (GM), and particularly facilitating in detection of WM abnormalities during disease progression. This study aims to optimize a quantitative R2 mapping method of rat brain at 7T MRI and to evaluate the relationship between the measured R2 values and myelin content in discrepant brain tissues. Our findings demonstrated that quantitative R2 measurements could be an alternative to provide information of myelin content in rat brain at 7T, which may have potential to assess microstructural changes of brain WM and GM in demyelinating diseases.

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