Abstract #2622

White Matter Tract Abnormalities are Associated with Cognitive Dysfunction in CADASIL

Shiyu Ban¹, Jingjing Su², Mengxing Wang¹, Shuai Xu¹, and Xiaoxia Du*¹

¹Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, School of Physics and Materials Science, East China Normal University, Shanghai, China, ²Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

This study was to investigate the white matter microstructural abnormalities and the relationship between white matter alterations and cognitive impairment in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), by diffusion tensor imaging (DTI). Patients with CADASIL showed significant extensive reductions in fractional anisotropy (FA), and increases in axial diffusivity (AD), radial diffusivity (RD), mean diffusivity (MD) compared to healthy controls. Furthermore, these white matter microstructural alterations were significantly correlated with Cognitive scores, and Stroke scale scores. It indicated that damage of white matter play an important role in cognition impairment in CADASIL

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