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Abstract #2623

Preoperative brain MRI features and postoperative delirium

Ilse M.J. Kant1,2, Jeroen de Bresser3, Simone J.T. van Montfort1, Myriam Jaarsma-Coes3, Theo Witkamp2, Henri J.M.M. Mutsaerts2, Claudia Spies4, Jeroen Hendrikse2, and Arjen Slooter1

1Department of Intensive Care, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 3Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 4Department of Anesthesiology and Operative Intensive Care Medicine, Charité Universitätsmedizin, Berlin, Germany

Postoperative delirium is associated with impaired cognitive outcome, longer hospital stay and an increased risk of dementia. To date, the pathophysiology of delirium remains largely unknown. Therefore, we studied the association of preoperative brain MRI features and the occurrence of postoperative delirium in a large group of older patients. We measured preoperative brain volumes, white matter hyperintensity shape, cerebral infarcts and cerebral perfusion. Preoperative cortical brain infarct volume was associated with postoperative delirium. Other preoperative brain MRI features were not significantly associated with postoperative delirium. Patients with a larger burden of cortical infarcts may have a decreased brain reserve, increasing the risk of postoperative delirium.

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