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Abstract #2628

Development and evaluation of a 0.5mm isotropic resolution structural template of the older adult brain

Mohammad Rakeen Niaz1, Abdur Raquib Ridwan1, Xiaoxiao Qi1, David A. Bennett2, and Konstantinos Arfanakis1,2

1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University, Chicago, IL, United States

Human brain structural MRI templates with low spatial resolution lack important fine details due to partial volume effects. The purpose of this work was twofold: a) to introduce a novel approach for high-resolution template construction based on principles of super-resolution, and b) using this technique, to develop a high-resolution structural template of the older adult brain based on MRI data from 222 non-demented older adults.

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