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Abstract #2627

Brain Microstructure Changes in Healthy Aging Revealed by Quantitative Multi-parametric MRI

Qixiang Lin1, Salman Shahid1, Antoine Hone-Blanchet1, Allan Levey1, James Lah1, Bruce Crosson1,2, and Deqiang Qiu2,3

1Department of Neurology, School of Medicine, Emory University, Atlanta, GA, United States, 2Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA, United States, 3Joint Department of BioMedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States

This study aims to reveal the alterations of biologically relevant measurements in healthy aging using multi-parametric quantitative MRI. Multi-parametric quantitative MRI scans of the whole brain were performed in 20 healthy elderly and 21 young adults. Whole-brain voxel-wise analysis showed increased quantitative T1 value in the right hippocampus and right insula, and widespread increases in the subcortical and cortical area of R2*, suggesting microstructural alteration associated with healthy aging in these regions. Quantitative multi-parametric measurements might provide sensitive neuroimaging biomarkers for the microstructure changes during normal aging and related neurodegeneration diseases.

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