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Abstract #2626

Sex differences in structural variability of brain regions in development and young adults

Natalie Forde1, Grace Jacobs1, Erin Dickie1, Aristotle Voineskos1,2, and Stephanie Ameis1,2

1CAMH, Toronto, ON, Canada, 2Psychiatry, University of Toronto, Toronto, ON, Canada

Increased variability of brain metrics is suggested to relate to increased vulnerability for psychiatric disorders.

Here we investigate sex differences in variability of brain structure (global and subcortical volume, regional cortical thickness and surface area) in young adults (n=1,032, 22-35 years, Human Connectome Project [HCP]) and through development (n=1,347, 8-21 years, Philadelphia Neurodevelopmental Cohort [PNC]).

Both volume and surface area were observed to be generally more variable in males compared to females in both development and adulthood. This increased variability may relate to the elevated vulnerability for psychiatric disorders seen in males compared to females.

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