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Abstract #2631

Evaluating lifespan tissue structure: Comparing CSD signal fraction and VBM grey matter density

Jamie C Blair1, Benjamin T Newman1, Lisa A Post2, and T Jason Druzgal1

1Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2University of Virginia, Charlottesville, VA, United States

Constrained spherical deconvolution (CSD), a recently developed diffusion MRI analysis technique, can be used to obtain whole-brain signal fractions from grey-matter-like, white-matter-like, and CSF-like tissue. This study evaluates the CSF compartment present in grey matter (GM-CSF) over the lifespan, and compares it to grey matter density (GMD), obtained through Voxel Based Morphometry. Results of this study reveal a complimentary relationship between GM-CSF and GMD across the lifespan, but not amongst a younger cohort. Results suggest further research is necessary to understand differences between these techniques, and how they may relate to tissue structure.

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