Abstract #2632

Characterizing age-related microstructural changes in locus coeruleus and substantia nigra

Jason Langley¹, Justino J. Flores², Sana Hussain³, Ilana J. Bennett², and Xiaoping Hu³

¹Center for Advanced Neuroimaging, University of California Riverside, Riverside, CA, United States, ²Department of Psychology, University of California Riverside, Riverside, CA, United States, ³Department of Bioengineering, University of California Riverside, Riverside, CA, United States

Characterization of age-related alterations in composition and morphology of locus coeruleus and substantia nigra pars compacta will aid in the development of new biomarkers and may provide insight in the development of novel interventions to arrest progression of Alzheimer's disease or Parkinson's disease. Imaging these structures with diffusion-weighted images is difficult due to their small stature (locus coeruleus is 1.5 mm in diameter and 15 mm long) and location in the brain stem. In this abstract, we utilize a high resolution diffusion-weighted protocol to examine age-related microstructural changes in locus coeruleus and substantia nigra pars compacta.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.