Aging is considered a major factor in the development of neurodegenerative disease. The aging process can result in brain tissue microstructural alterations, particularly in regions relevant to neurodegeneration, such as the substantia nigra (SN). In this study, we employed a non-Gaussian diffusion model – the continuous-time random-walk (CTRW) model – together with a high-resolution diffusion acquisition technique to investigate the possible microstructural changes in the SN in normal aging. Two CTRW model parameters have exhibited significant differences in the SN between young and elderly healthy human subjects.
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