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Abstract #2654

Test-retest Reproducibility and associations with cognitive impairment of 3D PCASL in Elderly Subjects at Risk of Small Vessel Disease

Kay Jann1, Xingfeng Shao1, Samantha J Ma1, Giuseppe Barisano1, Marlene Casey1, Lina M D'Orazio2, John M Ringman2, and Danny JJ Wang1

1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine at USC, Los Angeles, CA, United States, 2Neurology, Keck School of Medicine at USC, Los Angeles, CA, United States

We assessed the reproducibility 3D pCASL in an elderly cohort with risk for small vessel disease and its associations with clinical assessments and vascular risk factors. We found a high test-retest reproducibility of regional CBF and an association of subcortical MCA perfusion territories of the lenticulostriate arteries with cognition and vascular risks. Hence, 3D pCASL perfusion in MCA perfusion territory might be a potential imaging marker to identify early small vessel changes related to vascular cognitive impairment and dementia.

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