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Abstract #2690

Altered white matter microstructure correlates with cognitive functions in children and adolescents with bipolar disorder

Tianjia Zhu1,2, Chenying Zhao2,3, Minhui Ouyang2, Ruchir Arvind4, Johanna Saxena4, Sherin Kurian4, Kirti Saxena4, and Hao Huang2,5

1Department of Electrical and Systems Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 3Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, 4Baylor College of Medicine-Texas Children’s Hospital, Houston, TX, United States, 5Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Cognitive impairments and white matter (WM) microstructural alterations have been found in subjects with bipolar disorder (BD). However, the relationship between WM microstructural alterations and impulsivity, a prominent cognitive trait, in children/adolescents with BD is not known. In this study, diffusion MRI and cognitive assessments were obtained from 19 children/adolescents diagnosed with BD and 23 age-matched healthy controls. We found increased radial diffusivity(RD), reflecting disrupted myelin, in major WM tracts such as corpus callosum. Significant correlation between RD in WM tracts regulating impulsivity and response time to affective words was found, suggesting the association between WM myelin disruption and impulsivity.

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