Abstract #2690

Altered white matter microstructure correlates with cognitive functions in children and adolescents with bipolar disorder

Tianjia Zhu^1,2, Chenying Zhao^2,3, Minhui Ouyang², Ruchir Arvind⁴, Johanna Saxena⁴, Sherin Kurian⁴, Kirti Saxena⁴, and Hao Huang^2,5

¹Department of Electrical and Systems Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ³Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, ⁴Baylor College of Medicine-Texas Children’s Hospital, Houston, TX, United States, ⁵Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Cognitive impairments and white matter (WM) microstructural alterations have been found in subjects with bipolar disorder (BD). However, the relationship between WM microstructural alterations and impulsivity, a prominent cognitive trait, in children/adolescents with BD is not known. In this study, diffusion MRI and cognitive assessments were obtained from 19 children/adolescents diagnosed with BD and 23 age-matched healthy controls. We found increased radial diffusivity(RD), reflecting disrupted myelin, in major WM tracts such as corpus callosum. Significant correlation between RD in WM tracts regulating impulsivity and response time to affective words was found, suggesting the association between WM myelin disruption and impulsivity.

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