Abstract #2689

Studying disease-related brain alterations in bipolar disorder with combined analysis of DKI and VBM

Kouhei Kamiya^1,2, Naohiro Okada³, Kingo Sawada³, Kentaro Morita³, Susumu Morita³, Shintaro Kawakami³, Yuichi Suzuki⁴, Shiori Amemiya¹, Harushi Mori¹, Akira Kunimatsu¹, Koji Kamagata², Masaaki Hori², Shigeki Aoki², Kiyoto Kasai³, and Osamu Abe¹

¹Department of Radiology, the University of Tokyo, Tokyo, Japan, ²Department of Radiology, Juntendo University, Tokyo, Japan, ³Department of Neuropsychiatry, the University of Tokyo, Tokyo, Japan, ⁴Department of Radiology, the University of Tokyo Hospital, Tokyo, Japan

Brain abnormalities in bipolar disorder were investigated with diffusion kurtosis imaging and voxel-based morphometry, using a framework for data-driven feature extraction from multivariate data. The result showed two components capturing effect of diagnosis, and these were driven by diffusion kurtosis measures in the white matter including the prefrontal-striatal-thalamic pathways, cerebellum, and medial temporal lobes. Our results indicate diffusion kurtosis imaging can provide unique information that is sensitive to the abnormalities in bipolar disorder, and that interrelationship among different measures is a promising avenue to study neuronal circuits relevant to the disease.

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