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Abstract #2689

Studying disease-related brain alterations in bipolar disorder with combined analysis of DKI and VBM

Kouhei Kamiya1,2, Naohiro Okada3, Kingo Sawada3, Kentaro Morita3, Susumu Morita3, Shintaro Kawakami3, Yuichi Suzuki4, Shiori Amemiya1, Harushi Mori1, Akira Kunimatsu1, Koji Kamagata2, Masaaki Hori2, Shigeki Aoki2, Kiyoto Kasai3, and Osamu Abe1

1Department of Radiology, the University of Tokyo, Tokyo, Japan, 2Department of Radiology, Juntendo University, Tokyo, Japan, 3Department of Neuropsychiatry, the University of Tokyo, Tokyo, Japan, 4Department of Radiology, the University of Tokyo Hospital, Tokyo, Japan

Brain abnormalities in bipolar disorder were investigated with diffusion kurtosis imaging and voxel-based morphometry, using a framework for data-driven feature extraction from multivariate data. The result showed two components capturing effect of diagnosis, and these were driven by diffusion kurtosis measures in the white matter including the prefrontal-striatal-thalamic pathways, cerebellum, and medial temporal lobes. Our results indicate diffusion kurtosis imaging can provide unique information that is sensitive to the abnormalities in bipolar disorder, and that interrelationship among different measures is a promising avenue to study neuronal circuits relevant to the disease.

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