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Abstract #2688

Differences in Brain Microstructural Alterations between Bipolar and Major Depression Revealed by Diffusion Kurtosis Imaging

Daisuke Sawamura1, Khin Khin Tha2, Naoki Hashimoto3, Hisashi Narita3, Shin Nakagawa3, and Hiroki Shirato4

1Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, 2Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 3Hokkaido University Hospital, Sapporo, Japan, 4Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

This prospective study evaluated if bipolar and major depression patients had microstructural brain alterations detectable on DKI. The results showed significant alterations in these patients, of which some clusters correlated with clinical symptoms. Mean kurtosis also differed significantly between the two groups.

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