Abstract #2688

Differences in Brain Microstructural Alterations between Bipolar and Major Depression Revealed by Diffusion Kurtosis Imaging

Daisuke Sawamura¹, Khin Khin Tha², Naoki Hashimoto³, Hisashi Narita³, Shin Nakagawa³, and Hiroki Shirato⁴

¹Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, ²Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, ³Hokkaido University Hospital, Sapporo, Japan, ⁴Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

This prospective study evaluated if bipolar and major depression patients had microstructural brain alterations detectable on DKI. The results showed significant alterations in these patients, of which some clusters correlated with clinical symptoms. Mean kurtosis also differed significantly between the two groups.

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