Abstract #2687

The Importance of Identifying Functional Val158Met Polymorphism in Catechol-O- Methyltransferase (COMT) when Assessing MRI-based Volumetric Measurements in Major Depressive Disorder

Mario Serrano-Sosa¹, Kruthika Sampathgiri², Christine DeLorenzo², Ramin Parsey², and Chuan Huang^2,3

¹Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ²Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, ³Radiology, Stony Brook Radiology, Stony Brook, NY, United States

Using voxel-based morphology we investigated the relationship between COMT gene polymorphism and volumetric abnormalities in major depressive disorder patients and healthy controls. A significant difference in the right hippocampus (p=0.015) was found between the interaction of diagnosis and genotype, which suggests that COMT polymorphism must be considered during any volumetric analysis for depression.

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