Abstract #2686

Hippocampus-related regional and network functional deficits in first-episode drug-naïve major depressive disorder: a resting-state functional MRI study

Xiaoxiao Hu¹, Xinyu Hu¹, Hailong Li¹, Lianqing Zhang¹, Lu Lu¹, Xuan Bu¹, Shi Tang¹, Yingxue Gao¹, Yanlin Wang¹, Qiyong Gong¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, Chengdu, China

Previous neuroimaging studies have suggested that major depressive disorder (MDD) may be correlated with changes in regional- or network-level brain function. The purposes of the present study were to investigate changes of amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) in bilateral hippocampus by resting-state functional magnetic resonance imaging (rs-fMRI) in first-episode drug-naive major depressive disorder (MDD) patients. Our findings demonstrate that the hippocampus and dACC contribute to the underlying pathophysiology of MDD at an early-stage.

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