We performed a VBM analysis with DARTEL to
analysis the different structure in healthy controls,
MDD patients with or without suicidal actors. The result shows suicidal patients had
reduced GMV than patient controls in precuneus/cuneus, anterior cingulate
cortex and orbital frontal gyrus. Particularly,
we found suicidal ideators have reduced GMV in middle frontal gyrus compared to
suicidal attempters. Negative correlation was found between clinical characters
and volume of some regions. The dysfunction of self-awareness, emotional
processing and impulsivity control function caused by the abnormalities of
these brain regions may be associated suicidal behavior.
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