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Abstract #2684

Study of gender differences in major depressive disorder by using resting state brain functional magnetic resonance imaging

Lihua Qiu1,2, Lan Mei2, Jingping Mou2, Xinyu Hu1, and Qiyong Gong1

1Radiology, West China Hospital of Sichuan University, Chengdu, China, 2The Second People’s Hospital of Yibin, Yibin, China

Sex differences are observed in epidemiological and clinical symptoms of major depressive disorder (MDD); yet, little is known about about the gender difference of brain function in MDD. In this work, variance analysis were used to assess the sex differences of amplitude of low frequency fluctuation (ALFF) alterations in male, female MDD patients and matched controls. We found the gender differences of ALFF in bilateral caudate nucleus and posterior cingulate gyrus. Our findings suggest that sex specific functional alterations existed in MDD, and these alterations may associated with the clinical symptoms.

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