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Abstract #2683

Alterations of White Matter Tracts in Suicidal and Non-suicidal Brain with Major Depressive Disorder

Kaili Liang1,2, Xuan Bu1, Lianqing Zhang1, Yanli Wang1, Xinyu Hu1, Lu Lu1, Hailong Li1, Xiaoxiao Hu1, Shi Tang1, Yingxue Gao1, and Xiaoqi Huang1

1Huaxi Magnetic Resonance Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2West China School of Public Health, Sichuan University, Chengdu, China

We investigated the white matter alterations at the individual level in MDD patients with and without suicide attempts using Automated Fiber Quantification (AFQ) approach. The three major left hemispheric white matter tracts including arcuate, CST and ATR suggested to play an important role in suicidal brain, which implies deficits of dominant hemisphere specialization with cognitive processes such as reading, writing and speaking. Our study contributes to revealing neurobiological mechanism of suicide attempts.

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