Abstract #2682

Relationship Between Gray Matter Volume Reductions and TPH1 Polymorphisms in Depressive Disorder Patients with Suicidal Attempts

Geon-Ho Jahng¹, Jin Kyung Park², Seong Jong Yun¹, Chang-Woo Ryu¹, Wook Jin¹, and Dal Mo Yang¹

¹Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Psychiatry, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of

To investigate relationship between gray matter volume (GMV) changes and TPH1 polymorphisms in depressive disorder (DD) patients with suicidal attempts (SA), 13 DD-SA patients and 20 healthy controls were scanned three-dimensional (3D) T1-weighted image to obtain GMV in the brain. In addition, TPH1 rs1800532 and rs1799913 polymorphisms were obtained. The patients showed significant GMV reduction. The right precentral and postcentral gyri GMV values of AA and CA genotypes patients were significantly decreased compared to those of CC genotype subjects, indicating that both GMV reductions and TPH1 A allele may be involved in the pathogenesis of DD-SA patients.

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