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Abstract #2681

7 Tesla Phase Sensitive Imaging of Brain Regions with Metabolic Alterations in Major Depressive Disorder

Angela Jakary1, Audrey Yin1,2, Scott Mackin3, Stuart Eisendrath3, Janine Lupo1, and Yan Li1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UCSF, San Franciwsco, CA, United States, 3Psychiatry, UCSF, San Francisco, CA, United States

Ultra high-field phase sensitive imaging can help elucidate subtle changes in brain iron content. Recent research implicates brain iron deposition in the pathophysiology of major depressive disorder (MDD). Our previous work involving MDD patients detected symptom-related metabolic alterations in deep brain structures and anterior cingulate cortex. In our current analysis, we apply 7T phase sensitive imaging in these same brain regions to evaluate the role of iron accumulation in neurocognitive and depressive symptoms in this vulnerable population.

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