The reason for the inconsistency of bipolar disorder (BD) patients’ brain functional status and metabolic levels of treatment response is still not clear. This task-based fMRI study was carried out to figure out the relationship between medication treatment and brain status in function and metabolites. By analyzing functional connectivity and correlating metabolic markers in treatment response and no response BD patients, we found medication can affect the brain functional status and metabolic level in BD patients, and precentral gyrus is a key region during BD illness course.
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