Abstract #2696

Brain regional connectome-wide search identified a resting-state functional connectivity locus within precunes associated with rumination symptom severity in mood and anxiety disorders

Masaya Misaki¹, Aki Tsuchiyagaito^1,2, Obada A Zoubi^1,3, Martin Paulus¹, and Jerzy Bodurka^1,4

¹Laureate Institute for Brain Research, Tulsa, OK, United States, ²Japan Society for the Promotion of Science, Tokyo, Japan, ³Department of Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States, ⁴Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States

We identified a precise locus within the precuneus that has resting-state functional connectivity (rsFC) associated with rumination symptom severity for mood and anxiety (MA) disorder patients. We devised brain regional connectome-wide association analysis, which used multivariate distance matrix regression for searching voxels with connectivity correlated with the Ruminative Responses Scale (RRS) within the posterior cingulate cortex and the precuneus. The analysis identified voxels in the precuneus having rsFC significantly associated with RRS. Functional connectivity between the precuneus and bilateral temporoparietal junction (TPJ) had a significant positive correlation with RRS in MA patients but not in the healthy participants.

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