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Abstract #2696

Brain regional connectome-wide search identified a resting-state functional connectivity locus within precunes associated with rumination symptom severity in mood and anxiety disorders

Masaya Misaki1, Aki Tsuchiyagaito1,2, Obada A Zoubi1,3, Martin Paulus1, and Jerzy Bodurka1,4

1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Japan Society for the Promotion of Science, Tokyo, Japan, 3Department of Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States, 4Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, United States

We identified a precise locus within the precuneus that has resting-state functional connectivity (rsFC) associated with rumination symptom severity for mood and anxiety (MA) disorder patients. We devised brain regional connectome-wide association analysis, which used multivariate distance matrix regression for searching voxels with connectivity correlated with the Ruminative Responses Scale (RRS) within the posterior cingulate cortex and the precuneus. The analysis identified voxels in the precuneus having rsFC significantly associated with RRS. Functional connectivity between the precuneus and bilateral temporoparietal junction (TPJ) had a significant positive correlation with RRS in MA patients but not in the healthy participants.

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