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Abstract #2695

Association of explicit memory dysfunction with regional brain volume alterations in patients with generalized anxiety disorder

Chung Man Moon1,2 and Gwang Woo Jeong2

1National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States, 2Radiology, Chonnam National University Medical School, Gwangju, Korea, Republic of

Generalized anxiety disorder (GAD) causes emotional dysregulations and/or cognitive deficits, including excessive anger, impairments of explicit and implicit memories and poor attention. A DARTEL-based voxel-based morphometry (VBM) study for assessing the relationship between morphometric abnormalities and explicit memory dysfunction in patients with GAD has not yet been reported. Therefore, the purpose of this study is to investigate the regional gray matter (GM) and white matter (WM) volume alterations over the whole brain in patients with GAD, as well as the correlation between the brain structural abnormality and explicit memory dysfunction. Our findings would be helpful to understand the association between the brain structure abnormality and the functional deficit in the explicit memory in GAD.

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