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Abstract #2694

Stronger small-worldizition of structural networks in drug-naïve children and adolescents with ADHD:A graph theory analysis

Lu Lu1, Shi Tang1, Lianqing Zhang 1, Xinyu Hu1, Xuan Bu1, Hailong Li1, Xiaoxiao Hu1, Yingxue Gao1, Yanlin Wang1, John Adrian Sweeney1,2, Qiyong Gong1, and Xiaoqi Huang1

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, United States

Structural connectomes of patients with ADHD showed a shift toward “stronger small-worldization” which provided a structural basis for higher rates of information transfer in this disorder. These global network alterations, together with increased connectivity within and among DMN and task-positive networks including FPN, DAN and VAN, could lead to disruptions of attention and goal-oriented behavior that are the primary clinical hallmarks of ADHD.

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