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Abstract #2698

Functional and Structural Abnormality in Patients with Alcohol Use Disorder Combined VBM and FC Analysis

Yaqi Wang1 and Jun Chen1

1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China

We combined voxel-based morphometry (VBM) and seed-based functional connectivity (FC) analysis to identify functional and structural characteristics in patients with alcohol use disorder using high resolution T1-weighted structure images and functional MRI. AUD group showed significantly decreased gray matter volume mainly in the default mode network, and decreased FC in the default mode network and executive control network when compared with the HC group. Combining VBM and FC provides a new perspective on the pathophysiological and clinical manifestations in AUD patients.

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