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Abstract #2699

Along-tract statistics of NODDI diffusion metrics to enhance MR tractography quantitative analysis in healthy controls and in patients with glioma

Valentina Pieri1, Francesco Sanvito1, Sara Cirillo1, Marco Riva2,3, Andrea Falini1, and Antonella Castellano1

1Neuroradiology Unit and CERMAC, Vita-Salute San Raffaele University and IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy, 3Unit of Oncological Neurosurgery, Humanitas Research Hospital, Rozzano (MI), Italy

Along-tract statistical extraction of quantitative diffusion metrics is crucial to unravel the variability of these parameters within white matter fiber bundles. Here for the first time we extracted NODDI-derived microstructural diffusion estimates along the main eloquent fiber tracts in fifteen healthy subjects and in a pilot cohort of glioma patients. We constructed a robust reference database of normative along-tract microstructural values to describe the anatomical variability of NODDI metrics within tracts and to localize and quantify differences in pathological cases. Normal and pathological conditions can be statistically compared between-groups, as well as at the single-subject level.

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