Abstract #2733

Neurodegeneration of the substantia nigra after ipsilateral infarct: quantification with MRI R2* mapping and relationship to clinical outcome

Tourdias Thomas^1,2, Pierre Antoine Linck¹, Gregory Kuchcinski³, Fanny Munsch⁴, Romain Griffier⁵, Renaud Lopes³, Gosuke Okubo¹, Sharmila Sagnier⁶, Pauline Renou⁶, Julien Asselineau⁵, Paul Perez⁵, Vincent Dousset¹, and Igor Sibon⁶

¹Neuroimaging Dept., Bordeaux University hospital, Bordeaux, France, ²INSERM U1215, University of Bordeaux, Bordeaux, France, ³Neuroimaging Dept., Lille University hospital, Lille, France, ⁴Division of MRI research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ⁵USMR Dept., Bordeaux University hospital, Bordeaux, France, ⁶Neurology Dept., Bordeaux University hospital, Bordeaux, France

We tested whether long-term neurodegeneration of substantia nigra (SN) secondary to disconnection by supra-tentorial infarcts can be quantified with iron-sensitive imaging and contributes to clinical outcome. 181 stroke patients (75 striatum infarcts, 106 other locations) were prospectively evaluated at 24-to-72h and at one-year clinically and with MRI to quantify iron through R2*. We showed a delayed increase of R2* within SN that was strongly and independently associated with infarct location along known anatomic projections from SN. Such increase of R2* was an independent contributor of poor motor outcome. Iron-sensitive imaging can monitor neurodegeneration non-invasively within SN and potentially other areas.

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