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Abstract #2733

Neurodegeneration of the substantia nigra after ipsilateral infarct: quantification with MRI R2* mapping and relationship to clinical outcome

Tourdias Thomas1,2, Pierre Antoine Linck1, Gregory Kuchcinski3, Fanny Munsch4, Romain Griffier5, Renaud Lopes3, Gosuke Okubo1, Sharmila Sagnier6, Pauline Renou6, Julien Asselineau5, Paul Perez5, Vincent Dousset1, and Igor Sibon6

1Neuroimaging Dept., Bordeaux University hospital, Bordeaux, France, 2INSERM U1215, University of Bordeaux, Bordeaux, France, 3Neuroimaging Dept., Lille University hospital, Lille, France, 4Division of MRI research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 5USMR Dept., Bordeaux University hospital, Bordeaux, France, 6Neurology Dept., Bordeaux University hospital, Bordeaux, France

We tested whether long-term neurodegeneration of substantia nigra (SN) secondary to disconnection by supra-tentorial infarcts can be quantified with iron-sensitive imaging and contributes to clinical outcome. 181 stroke patients (75 striatum infarcts, 106 other locations) were prospectively evaluated at 24-to-72h and at one-year clinically and with MRI to quantify iron through R2*. We showed a delayed increase of R2* within SN that was strongly and independently associated with infarct location along known anatomic projections from SN. Such increase of R2* was an independent contributor of poor motor outcome. Iron-sensitive imaging can monitor neurodegeneration non-invasively within SN and potentially other areas.

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