Ischemic stroke (IS) may induce oxygenation alterations in brain regions remote to the lesion. Remote effect of IS in terms of oxygen metabolism was evaluated based on the voxel wise R2' quantification for subjects with first ever single lesioned IS in corona radiata (CR) (n=10) and brainstem (n=6) using R2' of the superior sagittal sinus as the reference. Both CR and brainstem IS groups showed significant changes of R2' in distributed brain regions with anatomical specifications, suggesting that IS rather represents a spectrum of pathophysiological events of hemodynamic and metabolic impairments at the global level than a focal vascular failure.
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