Abstract #2735

Age Specific Differences in Association Between White Matter Cerebral Blood Flow and Ischemic Lesion Severity

Hualu Han¹, Dongye Li¹, Huiyu Qiao¹, Dandan Yang¹, Zhensen Chen², Runhua Zhang^3,4, Gaifen Liu^3,4, and Xihai Zhao¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, ²Department of Radiology, University of Washington, Seattle, WA, United States, ³Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁴China National Clinical Research Center for Neurological Diseases, Beijing, China

White matter lesion (WML), one of the sequelae of cerebral hypoperfusion, accumulates with age. This study sought to investigate the relationship between cerebral blood flow (CBF) and WML severity with age in asymptomatic adults. We found that WML scores were strongly associated with WM CBF, suggesting that WM CBF might be an effective indicator for severity of WMLs. We also found that the WM CBF increased with age, consistent with the greater WM cerebrovascular reactivity response in elderly individuals. In addition, our findings of ascending WM CBF cut-off values revealed that the risk of developing WML increases with age.

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