Abstract #2742

Absolute quantitative dynamic susceptibility contrast cerebral perfusion imaging using the Self-Calibrated EPI sequence in patients with ischemic stroke

Xiaoyue Ma^1,2, Yan Wang^1,2, Qiang Li¹, Menghuan Zhang^1,2, Xianchang Zhang³, Yusong Lin⁴, and Meiyun Wang^1,2

¹Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, China, ²Henan Key Laboratory for Medical Imaging of Neurological Diseases, Zhengzhou, China, ³MR Collaboration, Siemens Healthcare Ltd., Beijing, China, ⁴Cooperative Innovation Center of Internet Healthcare & School of Software and Applied Technology, Zhengzhou University, Zhengzhou, China

This study aims to explore the clinical value of the absolute quantitative dynamic susceptibility contrast cerebral perfusion-weighted imaging using Self-Calibrated EPI sequence (SCALE-PWI) in patients with ischemic stroke. SCALE-PWI could provide reliable quantitative measurement of cerebral blood flow (CBF), cerebral blood volume and mean transit time in a quite short scan time of 2:14 mins. Results suggest the CBF values in infarct core are significantly lower than the values in ischemic penumbra. In conclusion, the SCALE-PWI could provide quantitative hemodynamic information in a quite short scan time, thus may serve as a guide for tissue-based decision making and personalized treatment planning in acute stroke.

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