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Abstract #2743

Disrupted structural brain network configuration in patients with post-stroke depression

Xiaopei Xu1, Rui Tang1, Siyu Zhu2, and Zhijian Cao3

1Department of Radiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 2Department of Medical Imaging, Sun Yat-sen University Cancer Center, Guangzhou, China, 3Department of Radiology, Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, China

To better understand the underlying mechanisms for a wide range of emotional disturbances in post-stroke depression (PSD) patients, we used structural brain connectivity analysis to investigate the differences in global and local network organization of stroke patients with PSD and no PSD. Our results demonstrated that the efficiency of both local and regional network of patients with PSD were higher compared to those without, and that higher depression severity was significantly associated with increased network efficiency. These results indicated that the disrupted network architecture might be the cause of depressive symptoms in PSD patients, and brain network analysis is a useful tool to link psychological disorders with their underlying anatomical substrate.

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