Abstract #2749

Myelin-associated clinical and physical correlates in a cohort of chronic schizophrenia patients.

Senften Peter¹, Melissa L Woodward², Randall F White³, Allen E Thornton⁴, Kristina Gicas³, Cornelia Laule^1,5,6,7, Darren E Warburton⁸, A. Talia Vertinsky¹, William G Honer³, Wayne Su³, and Donna J Lang¹

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Psychiatry, University of British Columbia, Vancouver, BC, Canada, ⁴Psychology, Simon Fraser University, Burnaby, BC, Canada, ⁵Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁷International Collaboration on Repair Discoveries (ICORD), University Of British Columbia, Vancouver, BC, Canada, ⁸Kinesiology, University of British Columbia, Vancouver, BC, Canada

Aberrant myelination and tandem cardiovascular deficits may contribute to emergence of the schizophrenias. To explore this hypothesis, a pilot study of Myelin Water Fraction (MWF), V02max capacity, and symptom severity was done in 15 chronic schizophrenia/schizoaffective patients. MWF was positively correlated with age in some, but not all, fronto-medial and fronto-temporal regions, 2. V02max was positively correlated with MWF the superior longitudinal fasciculus, the genu, and the forceps minor, and 3. Social functioning was positively correlated to MWF in the forceps major. These data indicate the presence of relationships between MWF measures, social functioning and cardiovascular capacity in schizophrenia.

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