Meeting Banner
Abstract #2750

Contribution and Interaction of Brain Structure and Function in Treatment Response Prediction of First-episode Drug-naïve Schizophrenia

GUI FU1, Ningxuan Chen2, Chaogan Yan2, Wenjing Zhang1, Jiaxin Zeng1, Yuan Xiao1, and Su Lui1

1Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Institution of Psychology, CAS, Beijing, China

Magnetic Resonance Imaging (MRI) including structural and functional neuroimaging has been applied extensively to examine response to antipsychotic treatment, however, questions remain regarding the interaction between these measurements and their unique role. Our study provided a comprehensive examination of interaction and contribution for voxel-wise measurements related with treatment response. We found that brain functional measurements in certain brain regions have advantages in predicting treatment response. Furthermore, the functional activities were different between short- and long-term treatment of antipsychotic drugs. These findings revealed that functional changes were more sensitive to the antipsychotic treatment and could be promising biomarkers in treatment prediction.

This abstract and the presentation materials are available to members only; a login is required.

Join Here