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Abstract #2751

Heterogeneity of brain structure alterations in patients with never-treated first episode schizophrenia

Yuan Xiao1, Bo Tao1, Jiaxin Zeng1, Gui Fu1, Biqu Tang1, Wenjing Zhang1, Siyi Li1, Su Lui1, and Qiyong Gong1

1West China Hospital of Sichuan University, Chengdu, China

Although schizophrenia is a heterogeneous clinical syndrome, one important question that remains largely unanswered is whether the complex and subtle deficits revealed by MRI could be used as objective biomarkers to resolve neurobiological heterogeneity within this disorder. Using clustering analysis and structural MRI, first-episode schizophrenia patients were classified into three subtypes. The three subtypes of patients showed different morphological alterations.

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