Abstract #2753

White matter microstructural changes in schizophrenia: A study using normative-model-based statistical analysis

Li-Ying Yang^1,2, Chih-Min Liu³, Tzung-Jeng Hwang³, Chang-Le Chen², Yung-Chin Hsu⁴, and Wen-Yih Isaac Tseng^2,5

¹Institute of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan, ²Institute of Medical Device and Image, National Taiwan University College of Medicine, Taipei, Taiwan, ³Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, ⁴AcroViz Technology Inc., Taipei, Taiwan, ⁵Molecular Imaging Center, National Taiwan University College of Medicine, Taipei, Taiwan

White matter microstructural changes have been found in schizophrenia but the effects of gender and age on these changes remains entangled. This study aimed to quantify the white matter changes in 158 schizophrenia patients using a novel approach which calculated the z scores based on the normative models built from 524 healthy subjects across lifespan. Our results showed that twelve tracts had significant differences between schizophrenia patients and controls.

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