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Abstract #2754

Gray matter network changes with aging and duration in a large group of never-treated patients with schizophrenia.

Beisheng Yang1, Wenjing Zhang2, Bo Tao2, Wenbing Li2, and Su Lui2

1Department of Radiology, West China Hospital, Sichuan University., Chengdu, China, 2West China Hospital, Sichuan University., Chengdu, China

A large group of never-treated schizophrenia patient was enrolled to investigate the pattern of network changes with aging and illness duration. Cortical thickness preprocessed by FreeSurfer, and correlation matrix was constructed by correlating the cortical thickness of every pair of regions. Compared to healthy controls, all patient subgroups stratified along age and illness duration showed common changes while distinct changes, mainly involved DMN and CN. The alternations within DMN and CN may represent trait-related structural network changes in schizophrenia, while distinct changes may represent illness progression with more-wide spread brain abnormalities.

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