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Abstract #2755

Evaluation of structural brain modifications related to First Episode Psychosis

Francesca Saviola1, Marcella Bellani2, Letizia Squarcina3, Eleonora Maggioni4, Domenico Zacà1, Cinzia Perlini5, Mirella Ruggeri2,6, Paolo Brambilla3,7, and Jorge Jovicich1

1CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto (TN), Italy, 2UOC of Psychiatry, Azienda Ospedaliera Universitaria Integrata (AOUI) of Verona, Verona, Italy, 3IRCCS “E. Medea” Scientific Institute, Bosisio Parini, Lecco, Italy, 4Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milano, Italy, 5Department of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Psychology, University of Verona, Verona, Italy, 6Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Italy, Verona, Italy, 7Department of Pathophysiology and Transplantation, University of Milan, Milano, Italy

Psychiatric disorders are characterized by a complex range of symptoms. Psychosis, known as one of the most severe mental illness, is still lacking specific neuroimaging markers complementing clinical information for early differential diagnostics, disease progression monitoring and treatment response evaluations. Most previous studies in the field considered psychotic patients undergoing chronic pharmacologic treatment or long duration of illness, which may confound morphometric or functional findings. Here we study a cohort of First Episode Psychosis (FEP) patients to investigated grey matter changes using structural MRI, in FEP relative to healthy controls, with univariate and multivariate analysis.

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