Abstract #2755

Evaluation of structural brain modifications related to First Episode Psychosis

Francesca Saviola¹, Marcella Bellani², Letizia Squarcina³, Eleonora Maggioni⁴, Domenico Zacà¹, Cinzia Perlini⁵, Mirella Ruggeri^2,6, Paolo Brambilla^3,7, and Jorge Jovicich¹

¹CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto (TN), Italy, ²UOC of Psychiatry, Azienda Ospedaliera Universitaria Integrata (AOUI) of Verona, Verona, Italy, ³IRCCS “E. Medea” Scientific Institute, Bosisio Parini, Lecco, Italy, ⁴Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milano, Italy, ⁵Department of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Psychology, University of Verona, Verona, Italy, ⁶Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Italy, Verona, Italy, ⁷Department of Pathophysiology and Transplantation, University of Milan, Milano, Italy

Psychiatric disorders are characterized by a complex range of symptoms. Psychosis, known as one of the most severe mental illness, is still lacking specific neuroimaging markers complementing clinical information for early differential diagnostics, disease progression monitoring and treatment response evaluations. Most previous studies in the field considered psychotic patients undergoing chronic pharmacologic treatment or long duration of illness, which may confound morphometric or functional findings. Here we study a cohort of First Episode Psychosis (FEP) patients to investigated grey matter changes using structural MRI, in FEP relative to healthy controls, with univariate and multivariate analysis.

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