Psychiatric disorders are characterized by a complex range of symptoms. Psychosis, known as one of the most severe mental illness, is still lacking specific neuroimaging markers complementing clinical information for early differential diagnostics, disease progression monitoring and treatment response evaluations. Most previous studies in the field considered psychotic patients undergoing chronic pharmacologic treatment or long duration of illness, which may confound morphometric or functional findings. Here we study a cohort of First Episode Psychosis (FEP) patients to investigated grey matter changes using structural MRI, in FEP relative to healthy controls, with univariate and multivariate analysis.
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