Abstract #2756

Quantitative Susceptibility Mapping MRI shows changes in dorsal striatum in patients with a first Episode of Psychosis compared to controls.

Marisleydis García^1,2,3, Néstor Muñoz^1,2,3, Manuel Chappa^1,2,3, Carlos Milovic^1,2,3, Cristian Montalba^2,3,4, Julio Acosta-Carbonero⁵, Luz María Alliende⁶, Bárbara Iruretagoyena⁶, Juan Undurraga⁷, Alfonzo González⁷, Carmen Paz Castañeda⁷, Marcelo Andia^2,3,4, Sergio Uribe^2,3,4, Nicolas Crossley^2,6, and Cristián Tejos^1,2,3

¹Departament Electrical Engineer, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile, ²Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile, ³Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago de Chile, Chile, ⁴Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile, ⁵Wellcome Centre for Human Neuroimaging, University College London, London, United Kingdom, ⁶Pontificia Universidad Católica de Chile, Santiago de Chile, Chile, ⁷Instituto Psiquiátrico Horwitz, Santiago de Chile, Chile

Dopamine is a neurotransmitter that plays an important role in psychosis. Neuromelanin is a by-product of the synthesis of dopamine. In First Episode of Psychosis (FEP) is reported the effect that causes dopamine and its relationship with neuromelanin. However, it has not been reported signal change due to accumulation of heavy metal using magnetic resonance imaging techniques. We found susceptibility changes in two areas of brain using QSM, the left subthalamic nucleus and right caudate. This finding might help to discriminate between FEP patients and healthy subjects.

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