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Abstract #2757

Brain morphometric and cellular metabolic alterations in patients with obsessive–compulsive disorder

Chung Man Moon1,2 and Gwang Woo Jeong2

1National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, United States, 2Radiology, Chonnam National University Medical School, Gwangju, Korea, Republic of

Obsessive–compulsive disorder (OCD) causes neural dysfunction associated with cognitive deficit and emotional dysregulation. To our knowledge, however, no one has applied the combined neuroimaging study of morphometric and metabolic brain abnormalities in patients with OCD. Therefore, this study assessed the associations of the gray matter (GM) and white matter (WM) volume alterations in conjunction with in vivo cellular metabolic changes in patients with OCD. Our findings will be helpful to aid us in the understanding of neurocognitive impairment in OCD, and thus, enhancing the diagnostic accuracy for OCD by additional information on the associated cerebral volume change and metabolic abnormality.

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