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Abstract #2759

Alterations of structural anatomy and functional connectivity regarding hippocampus in obsessive–compulsive disorder

Xinyu Hu1, Lianqing Zhang1, Xuan Bu1, Hailong Li1, Bin Li2, Wanjie Tang2, Lu Lu1, Xiaoxiao Hu1, Shi Tang1, Yingxue Gao1, Yanlin Wang1, Yanchun Yang2, Qiyong Gong1, and Xiaoqi Huang1

1Huaxi MR Research Centre(HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Mental Health Center, Department of Psychiatry, West China Hospital of Sichuan University, Chengdu, China

Besides the classical cortico-striato-thalamo-cortical circuits, the hippocampus has received increasing attention in the psychopathology of obsessive-compulsive disorder (OCD). We aimed to investigate the abnormalities of structural anatomy and functional connectivity (FC) regarding hippocampus in a relatively large sample of unmedicated OCD patients and explore the effects of onset age on these neural correlates. Our findings (i) identified significant volumetric reductions of right hippocampus in OCD; (ii) revealed abnormal cortico-hippocampal connectivity in the prefrontal-limbic networks of OCD and (iii) indicated distinct patterns of cerebral-hippocampal connectivity alterations in early-onset and late-onset OCD, which highlighted the potential importance of neurodevelopmental changes in OCD.

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