Besides the classical cortico-striato-thalamo-cortical circuits, the hippocampus has received increasing attention in the psychopathology of obsessive-compulsive disorder (OCD). We aimed to investigate the abnormalities of structural anatomy and functional connectivity (FC) regarding hippocampus in a relatively large sample of unmedicated OCD patients and explore the effects of onset age on these neural correlates. Our findings (i) identified significant volumetric reductions of right hippocampus in OCD; (ii) revealed abnormal cortico-hippocampal connectivity in the prefrontal-limbic networks of OCD and (iii) indicated distinct patterns of cerebral-hippocampal connectivity alterations in early-onset and late-onset OCD, which highlighted the potential importance of neurodevelopmental changes in OCD.
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