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Abstract #2760

Abnormal Static and Dynamic Functional Network Connectivity Patterns in Patients with Obsessive-compulsive Disorder

Hailong Li1, Yingxue Gao1, Xuan Bu1, Xinyu Hu1, Lianqing Zhang1, Lu Lu1, Shi Tang1, Xiaoxiao Hu1, Kaili Liang1, Yanlin Wang1, Qiyong Gong1, and Xiaoqi Huang1

1Huaxi Magnetic Resonance Research Centre (HMRRC), West China Hospital of Sichuan University, Chengdu, China

Static and dynamic functional network connectivity (FNC) analyses were applied to determine the abnormal connectivity patterns among the large-scale brain networks in obsessive-compulsive disorder patients. We found that static FNC analysis showed more obvious group differences than dynamic FNC. Decreased functional connectivity between visual network and DMN has been shown in both static and dynamic FNC analysis, it could be considered as the most stable connectivity change of functional brain networks in OCD patients. These findings advocate the using of both static and dynamic FNC to help truly understanding the alterations of brain networks.

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