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Abstract #2772

Altered white matter microstructure in anorexia nervosa: A voxel-based meta-analysis of diffusion tensor imaging

Simin Zhang1, Weina Wang1, Xiaorui Su1, Huaiqiang Sun1, Qiang Yue2, and Qiyong Gong1

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Radiology, West China Hospital of Sichuan University, Chengdu, China

The neurobiological underpinnings of anorexia nervosa (AN) remain unclear. Altered white matter microarchitecture has been described, but findings are inconclusive. To investigate a statistical consensus among published DTI studies of altered white matter microarchitecture in AN, we conducted a quantitative voxel-based meta-analysis of fractional anisotropy using Seed-based d Mapping. The pooled results in AN showed robust reduction fractional anisotropy in the interhemispheric connections, frontal-subcortical circuitry and limbic association fibers. This study provides a thorough profile of WM microarchitecture alterations in patients with AN and these intrinsic alterations may aid in developing effective treatments in AN.

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