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Abstract #2780

Fully-automatic quantitative susceptibility mapping of the precentral gyrus in motor neuron disease

Valeria Elisa Contarino1,2, Giorgio Conte1, Claudia Morelli2, Sonia Francesca Calloni1, Luis Carlos Sanmiguel Serpa3, Elisa Scola1, Francesca Trogu2, Vincenzo Silani2,4, and Fabio Triulzi1,4

1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy, 2Istituto Auxologico Italiano, Milano, Italy, 3Politecnico di Milano, Milano, Italy, 4Università degli Studi di Milano, Milano, Italy

The diagnosis of Motor Neuron Disease (MND) is a long process that involves careful clinical and neurological examination during a long period of time. As iron overload is recognized as one of the main pathogenic mechanisms, previous studies focused on hand-drawn ROI-based measures of susceptibility in the precentral gyrus in MND. In contrast to the manually drawn ROIs approach guided by pathology localization and lateralization, this study suggests that the building of a MND biomarker might rely on susceptibility properties of the precentral gyrus measured on clinical images with a fully-automatic pipeline.

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