Abstract #2780

Fully-automatic quantitative susceptibility mapping of the precentral gyrus in motor neuron disease

Valeria Elisa Contarino^1,2, Giorgio Conte¹, Claudia Morelli², Sonia Francesca Calloni¹, Luis Carlos Sanmiguel Serpa³, Elisa Scola¹, Francesca Trogu², Vincenzo Silani^2,4, and Fabio Triulzi^1,4

¹Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy, ²Istituto Auxologico Italiano, Milano, Italy, ³Politecnico di Milano, Milano, Italy, ⁴Università degli Studi di Milano, Milano, Italy

The diagnosis of Motor Neuron Disease (MND) is a long process that involves careful clinical and neurological examination during a long period of time. As iron overload is recognized as one of the main pathogenic mechanisms, previous studies focused on hand-drawn ROI-based measures of susceptibility in the precentral gyrus in MND. In contrast to the manually drawn ROIs approach guided by pathology localization and lateralization, this study suggests that the building of a MND biomarker might rely on susceptibility properties of the precentral gyrus measured on clinical images with a fully-automatic pipeline.

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