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Abstract #2781

The Splenial Angle: A Novel Index in Idiopathic Normal Pressure Hydrocephalus

Ling Ling Chan1,2, Robert Chen1, Wei Ying Go1, Huihua Li2,3, Soo Lee Lim1, Sumeet Kumar4, and Nicole Chwee Har Keong5

1Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3Health Services Research Unit, Singapore General Hospital, Singapore, Singapore, 4Neuroradiology, National Neuroscience Institute, Singapore, Singapore, 5Neurosurgery, National Neuroscience Institute, Singapore, Singapore

The callosal angle (CA) is a useful tool in idiopathic normal pressure hydrocephalus (iNPH) for diagnosis and patient selection for shunt surgery. We evaluated for (1) differences in a novel splenial angle (SA) in iNPH compared to healthy controls (HC), and (2) temporal changes in SA, CA and Evan’s index in shunted and non-shunted iNPH patients. Significant differences (p<0.0001) existed in the EI, CA and SA between iNPH and HC. Amongst iNPH patients with or without shunting, significant temporal changes were also found in in all indices on follow-up MRI scans compared to baseline measurements.

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